News: From the Bench

The Impact of MITF on Melanoma Development – News from Bench and Bedside

In the current issue, two articles highlight the impact of melanocyte transcription factor (MITF) on melanoma development. In the first, Lister et al. reveal in vivo proof of MITF directly regulating tumor development in BRAF(V600E) melanomas. In the second, Sturm et al. present a clinical trial that emphasizes the importance of the recently discovered E318K MITF germline mutation in patients w...

From theory to bench confirmation or from bench to theory

In this commentary, the authors discuss two possible approaches in experimental studies. The first approach is to replicate an experimentation in order to confirm or not previously published results. The second one is more theoretical and consists in estimating the expected effect of all the components of the problem. When theoretical calculations suggest a theoretical failure that contradicts ...

News from the Field

B O S T O N UNIVERSITY LIB R AR Y has been given a valuable collection of Lincoln letters, documents a n d related materials, number ing eighty-six items. Of special interest is an order to Genera l Winf ie ld Scott to susp e n d the writ of habeas corpus. T h e donor is the H o n o r a b l e Edward C. Stone, a member of the Massachusetts Senate a n d chairm a n of the Board of Trus tees of the...

News from the Archives

Why do so many scientific research articles languish in obscurity? There is no single answer. No doubt many have earned their ignominy by their flawed scholarship, poor exposition, or arcane subject matter, but this is not always the case. A search of the old literature often uncovers many seemingly worthy contributions that have inexplicably fallen into oblivion. Probably the most common reaso...

News from the field